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KMID : 0363320190400010154
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Journal of Korean Oriental Internal Medicine
2019 Volume.40 No. 1 p.154 ~ p.163
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Administration Progression and Adverse Event Report of Er-Xian Decoction for Menopausal Hot Flushes: Case Report and Review of Literature
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Kim Bo-Min
Jo Hee-Geun
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Abstract
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Objective: We report on the administration progression and adverse event of Er-Xian decoction for menopausal hot flushes. A hot flush is a rapid and intense heat-dissipation reaction that involves considerable sweating, enlargement of the peripheral blood vessels, and internal body heat. Er-Xian decoction is a prescription for treating menopausal hot flush symptoms in postmenopausal women. We report administration progression and adverse event of Er-Xian decoction for menopausal hot flush.
Methods: We used the Menopause Rating Scale and Menopause-Specific Quality of Life questionnaire to evaluate the progression of hot flushes, and we conducted a literature review to determine the effective dosage of Er-Xian decoction.
Result: In all cases, Facial hot flushes and evaluation variables were improved by the administration of EXD. However, in Case 1, a rise of liver function indexes which may be related to EXD administration was observed.
Conclusion: Considering that menopausal flushing usually lasts for several years, The resluts are meaningful that the short-term administration of EXD led to improvement of symptoms. In order to further use EXD in the future, it will be necessary to conduct follow-up studies on the subject of safety verification, such as repeated dose toxicity studies.
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KEYWORD
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menopause, menopausal syndrome, hot flush, herbal medicine, Er-xian decoction
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